Freeze Drying Process – Simulation of Pharmaceutical, Chemical and Food Freeze Drying Processes

Freeze Drying Process – Simulation of Pharmaceutical, Chemical and Food Freeze Drying Processes: "Freeze Drying Process - PASSAGEâ/Freeze Drying SoftwarePassage®/FreezeDrying is a computer program designed for the simulation of freeze drying processes in vials and pans.
Passage®/FreezeDrying provides modeling of containers with axisymmetric boundary conditions with both primary and secondary drying simulation capabilities. The software also handles containers with asymmetric boundary conditions, as in the case of vials placed in corners or near the walls of freeze-drying ovens.
The user-friendly, interactive preprocessor accepts externally generated meshes and support automatic entry of material properties, process conditions, and display of geometry.
Passage®/FreezeDrying also has user-friendly, interactive post-processing modules which display the computed temperature, vapor concentration, water pressure, and glass transition distributions in the form of contour plots and x-y graphs. Animation of sublimation front movements can also be obtained easily.
Some objectives of using CAE is to identify freeze drying process conditions to:
Maximize drying rate and increase production
Prevent chemical & structural degradation
Provide uniform drying throughout the material
Predict drying time for primary and secondary stages to desired levels of water concentration

Some results of the analysis:
Time for primary and secondary drying of products
Location for isolated islands of ice in pan drying
Concentration contours
Absorbed water concentration
Interface position in time
Sublimation frontal movement
Temperature contours and history
Water pressure contours

FreezeDrying brochure "